Synthetic Vocal Cord gel could restore function to damaged vocal chords

Posted on Friday, July 15, 2011 by Unknown

Whether caused by intubation during surgery, laryngeal cancer, lesion removal, or simply overuse, vocal cord scarring can limit or even eliminate some peoples' ability to speak. This is because the scar tissue is stiff, and doesn't allow the vocal cords to vibrate adequately. Some doctors have tried to soften the tissue using materials from the fields of plastic surgery and dermatology, but the treatment doesn't work in all cases, and the effects are said not to last very long. Researchers from the Massachusetts Institute of Technology (MIT) and Harvard Medical School, however, are developing a new approach - an injectable gel that mimics vocal cord tissue.

Rather than approaching the problem as a physiological one, they looked at the vocal cords as a mechanical issue. That is, they didn’t attack the scar tissue in the vocal cords but devised a fix for it. That fix came in the form of a material known as polyethylene glycol (PEG), which they chose because it is already FDA approved for other medical applications.

Lab tests have also shown that it can restore vibration to stiffened, scarred vocal cords. The MIT/Harvard project is attempting to restore vocal functions despite the presence of scar tissue, while other approaches (such as those involving drug treatments) have focused more on trying to get rid of that tissue.

Their PEG30 gel, should it receive its own FDA approval, would be categorized as an injectable medical device rather than a drug, which could further speed it to market. If approved, it would have to be re-injected every six months or so because it breaks down over time. But it could restore voice to many who have lost their primary means of expression.

The video below shows how the gel performs, as compared to actual vocal cords.